The model of cell rheological parameters determination

Abstract

Proposed the model of cell rheological parameters determination based on nanoindentation. It is assumed that shapes of cell and indenter are known, which allows to get stats for creep kernel of normal cell and to diagnose systematic disease based on stats aberration. The method is based on solution of the direct indentation problem (indentation of curvilinear biological finite-size object with a rigid stamp of an arbitrary shape). Complicated spatial creep problem is reduced to two contact problems, which are solved based on generalization of the Winkler model and using the hereditary creep theory.